Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles.
نویسندگان
چکیده
A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 100 شماره
صفحات -
تاریخ انتشار 2012